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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis

Fig. 3

Pathological features of case five of histology, IHC and electron microscopy. a) Diffuse fibrosis with obliteration of most tubules and isolation of glomeruli (×40) HE. b) Typical storiform fibrosis with abundant inflammation cells (×200) PAM. c) Rich collagen fibrosis and characteristic bird’s-eye pattern (×200) Masson trichrome staining. d) Characteristic bird’s-eye pattern (×400) PAM. e) Abundant, evenly distributed, strong positive plasma cells in interstitium by CD138 test (×100) IHC. f) Abundant strong stained and evenly distributed IgG4+ plasma cells (>50 per HPF) in interstitium and tubular epithelial cells by IgG4 test (×200) IHC. g) Apparent TBM deposition of two tubules by IgG test (×200) IHC. h) Thickened TBM with scattered electron dense immune complex deposits (×4000) EM

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