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Table 1 Two proposed criteria for IgG4-TIN by the Mayo Clinic and JSN

From: Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis

Criterion The Mayo Clinic criteria JSN criteria
Histology Plasma cell-rich TIN with >10 IgG4+ plasma cells/HPF field in the most concentrated field (mandatory criterion) a. Dense lymphoplasmacytic infiltrate with >10 IgG4+ plasma cells/HPF and/or IgG4/IgG+ plasma cell ratio of >40 %
  TBM immune complex deposits by immunofluorescence, immunohistochemistry, and/or electron microscopy b. Characteristic storiform fibrosis
Imaging Small peripheral low-attenuation cortical nodules, round or wedge-shapped lesions, or diffuse patchy involvement Multiple low-density lesions on enhanced CT, diffuse kidney enlargement, hypovascular solitary nodule, hypertrophic lesion of the renal pelvic wall
Serology Elevated serum IgG4 or total IgG level Elevated serum IgG4 or total IgG level
Clinical features None Clinical or laboratory evidence of kidney damage
Other organ involvement Characteristic findings of IgG4-RD in other organs Characteristic findings of IgG4-RD in other organs
Definite IgG4-TIN The histologic feature and at least one other feature from imaging, serology or other organ involvement The histologic feature (a and b) and at least two of other features from imaging, serology or other organ involvement