Table 3 Clinical, radiographic, laboratory and pathological features of twelve high-probability IgG4-TIN cases
From: Evaluation of diagnostic criteria for IgG4-related tubulointerstitial nephritis
Pt No. | Age/Gender | Clinical Diagnosis | Proteinuria (0.01-0.15g/24h) | Hematuria | ALB (35-55 g/L) | SCr (44-132μmol/L) | eGFR (80-120ml/min) | Serum IgG (751-1560mg/dL) | Serum C3 (79-152 mg/dL) | Principal Pathological Diagnosis | IgG4 (cells/HPF) | IgG4/IgG (%) | Storiform fibrosis | Stage of Fibrosis | TBM Deposits | Imaging Findings | Other Organ Involvement |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 65 M | ARF | 0.30 | - | 36 | 381 | 13.2 | 1910 | 67 | Idiopathic TIN | 14 | 23.3 | - | 0 | - | Bilateral Enlarged | - |
2 | 42 F | ARF, AAV | 1.41 | 4+ | 35 | 447 | 9.9 | 2370 | 78 | Pauci-immune CreGN | 22 | 56.7 | - | 0 | + | - | - |
3 | 52 F | SLE, CRF | 1.57 | 2+ | 30 | 273 | 15.5 | 3050 | 86 | LN | 11 | 84.6 | - | 1 | + | - | PF |
4 | 76 M | CGN, CRF | 1.41 | 4+ | 33 | 380 | 11.9 | 1990 | 75 | Immune complex CreGN | 10 | 43.5 | - | 1 | - | - | PF |
5 | 62 M | CGN, CRF | 1.17 | - | 30 | 234 | 25.6 | 4050 | 45 | Idiopathic TIN | 55 | 93.2 | + | 2 | + | Bilateral Enlarged | PF Lymph node Enlarged |
6 | 49 M | CGN, CRF | 0.40 | 3+ | 37.6 | 138 | 52 | 1050 | 81 | IgAN | 12 | 32.2 | - | 1 | + | - | PF |
7 | 33 F | ARF | 0.21 | - | 39.9 | 231 | 24.9 | 2010 | 123 | Drug-induced TIN | 22 | 58 | - | 1 | + | - | - |
8 | 59 M | ARF | 0.60 | 3+ | 26.6 | 1108 | 10.7 | 1380 | 86 | Anti-GBM CreGN | 29 | 60.3 | - | 1 | - | - | PF |
9 | 36 F | CGN, CRF | 2.69 | 3+ | 30.4 | 199 | 40.7 | 1910 | 121 | IgAN | 14 | 40.3 | - | 2 | + | - | - |
10 | 56 F | ARF, AAV | 1.58 | 3+ | 26.9 | 1832 | 5.4 | 2120 | 80 | Crescentic IgAN | 20 | 95 | + | 1 | + | - | PF |
11 | 59 M | ARF | 0.49 | - | 25.7 | 586 | 8.4 | 1860 | 106 | Immune complex CreGN | 52 | 91 | + | 2 | + | Bilateral Enlarged | - |
12 | 30 F | CGN,CKD2 | 0.61 | - | 42.1 | 105 | 65.3 | 1870 | 109 | IgAN | 25 | 63.7 | - | 2 | + | - | - |