Table 2 Correlation between serum RASSF1A methylation status and clinico-pathological features of HCC [n (%)]
Characteristics | Case (n = 190) | RASSF1A methylation positive (n = 122) | χ 2 | P |
|---|---|---|---|---|
HBeAg | ||||
Positive | 96 (50.5) | 71 (58.2) | 1.757 | 0.185 |
Negative | 94 (49.5) | 51 (41.8) | ||
Tumor number | ||||
Single | 128 (67.4) | 84 (68.9) | 0.075 | 0.784 |
Multiple | 62 (32.6) | 38 (31.1) | ||
Tumor size | ||||
< 5 cm | 92 (48.4) | 50 (41.0) | 1.657 | 0.198 |
≥ 5 cm | 98 (51.6) | 72 (59.0) | ||
Histological grading | ||||
I + II | 134 (70.5) | 69 (56.6) | 6.378 | 0.012 |
III + IV | 56 (29.5) | 53 (43.4) | ||
TNM stage | ||||
I + II | 68 (35.8) | 26 (21.3) | 7.859 | 0.005 |
III + IV | 122 (64.2) | 96 (78.7) | ||
Portal venous invasion | ||||
Yes | 122 (64.2) | 62 (50.8) | 5.506 | 0.019 |
No | 68 (35.8) | 60 (49.2) | ||
Liver cirrhosis | ||||
Yes | 118 (62.1) | 64 (52.5) | 2.844 | 0.092 |
No | 72 (37.9) | 58 (47.5) |