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Table 2 Clinicopathological and Immunohistochemical Characteristics in CRCs. Fez, Morocco, 2010-2013

From: Epigenetics could explain some Moroccan population colorectal cancers peculiarities: microsatellite instability pathway exploration

Characteristics Frequencies (%)
Gender (n = 385) Male 51.4
Female 48.6
Age rang (n = 385) <50 years 36.5
>50 years 63.5
Individual or family history of cancer belonging to HNPCC spectrum (n = 208) Yes 10.1
No 89.9
Localization (n = 385) Ascending colon 14.4
Transverse colon 4.8
Descending colon 4.8
Sigmoid 17.9
Recto-sigmoid junction 9.1
Upper rectum 6.7
Through rectum 20.6
Lower rectum 21.7
Histologic type (n = 385) Adenocarcinoma 88.1
Mucinous carcinoma 8.6
Independent cells carcinoma 3.4
Histological differentiation (n = 385) Well 66
Average 26.5
Poor 6.8
Undifferentiated 0.8
Mucinous component (n = 385) Yes 16.1
No 83.9
Independent cells component (n = 385) Yes 6
No 94
Vascular embolus (n = 270) ((surgical specimens only) Yes 16.1
No 83.9
Perineural invasion (n = 270) (surgical specimens only) Yes 9.9
No 90.1
Synchronous colorectal lesion (n = 359) Cancer 3.9
Single adenoma 11.4
Multiple adenomas 3.1
No 81.6
Stage pT (n = 222) (only surgical specimens without radiochemotherapy) 1 0.5
2 12.6
3 78.4
4b 8.6
Lymph node metastasis(n = 270) (surgical specimens only) Yes 29.6
No 60.4
Stage pN (n = 270) (surgical specimens only) 0 60.4
1mic 0.4
1a 12.6
1b 10.7
2a 8.9
2b 7
Radiological or/and pathological aspect of extension to adjacent organs (n = 303) Yes 13.9
No 86.1
Visceral metastasis (n = 285) Yes 26.3
No 73.7
Peritoneal carcinomatosis (n = 288) Yes 15.6
No 84.4
Stage M (n = 285) 0 65.6
1a 14.4
1b 20
Expression of MMR proteins (IHC) (n = 214) Loss 11.2
Conservation 88.8
MMR proteins not expressed (n = 24) MLH1 and PMS2 66.7
MSH2 and MSH6 33.3