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Table 4 Clinicopathological characteristics in CRCs with MMR proteins expression loss/conservation. Fez, Morocco, 2010-2013

From: Epigenetics could explain some Moroccan population colorectal cancers peculiarities: microsatellite instability pathway exploration

Characteristics Loss of expression of MMR proteins Conservation of expression of MMR proteins Univariate analysis (p) Multivariate analysis
p Odds ratio
Means Age (years) 55.1 56.4 0.7   
Age rang < 50 years 8/24 60/190 0.48   
Presence of individual or family history of cancer belonging to HNPCC spectrum 4/9 9/190 0.001 0.01 35.8 [95 % CI 2.2- 588]
Well or moderately differentiated adenocarcinoma 15/24 145/190 0.07   
Presence of independent cells component 2/24 13/190 0.52   
Presence of mucinous component 5/24 33/190 0.43   
Presence of perineural invasion 1/19 12/139 0.51   
Presence of vascular embolus 4/19 21/139 0.35   
Presence of lymph node metastasis 3/19 53/138 0.02   
Presence of synchronous colorectal cancer 6/23 5/185 0.0003   
Presence of radiological or/and pathological extension to adjacent organs 4/21 16/147 0.22   
Presence of visceral metastasis 6/17 31/132 0.21   
Presence of peritoneal carcinomatosis 4/20 21/146 0.35   
Location - - 0.00001 0.02 21 [95 % CI 1.4-316.3]
Right colon 14/23 31/184 - -  
Left colon 6/23 64/184 - -  
Rectum 3/23 89/184 - -