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Table 1 Pathological, immunophenotypical and genotypical findings

From: Aggressive natural killer-cell neoplasm presenting in the marrow: a report of two cases including one with gains of chromosomes 4q and 9p

 

Case 1

Case 2

Cell size

Small to medium

Small to medium

Tumor necrosis

Absent

Present

CD2

-

-

CD3

+

+

sCD3 (FCM)a

-

ND

CD4

-

-

CD5

-

-

CD7

-

+

CD8

-

+

CD16

ND

-

CD30

ND

-

CD56

-

-

CD56 (FCM)*

+

ND

TIA-1

+

+

Granzyme B

-

-

βF1

-

-

TCR-γ

-

-

TCR-GR

Polyclonal

Polyclonal

  1. aFCM, flow cytometric immunophenotyping using bone marrow aspirate
  2. Abbreviations: ND, not done; sCD3, surface CD3; TCR-GR, T-cell receptor gene rearrangement