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Fig. 2 | Diagnostic Pathology

Fig. 2

From: RETRACTED ARTICLE: HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-κB and cGMP dependent mechanisms

Fig. 2

HMGB1 directly induces platelet aggregation, results are expressed as mean ± SE. The data shown here are representatives of at least five experiments from different donor. a Various concentrations of HMGB1 protein induced platelet aggregation curves, albumin (ALB) is negative control, (b). Record data are means the maximum platelet aggregation rate induced by HMGB1 (n = 5, *P < 0.05 vs. ALB group). c and d The effects of PMB or proteinase K on HMGB1-induced platelet aggregation curves. HMGB1 (40 μg/ml) were pretreatmented with PMB (1 μg/ml) or proteinase K (500 μg/ml PK) for 10 min at RT, or thermal denaturation of HMGB1 (TD) at 100 °C for 10 min respectively, rHMGB1-induced platelet aggregation were obvious inhibited by PK or treatment of thermal denaturation, but not affected by PMB. (n = 5, *P > 0.05; **P < 0.05. vs HMGB1 group)

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