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Fig. 5 | Diagnostic Pathology

Fig. 5

From: RETRACTED ARTICLE: HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-κB and cGMP dependent mechanisms

Fig. 5

HMGB1-induced platelet aggregation depends on GPIIb-IIIa. a the results of the flow cytometric analysis of a patients with Glanzmann thrombasthenia (GT), CD41a and CD61 only expressed 0.7 % and 0.5 % respectively. b HMGB1 was incapable of promoting platelet aggregation in patients with GT, as positive control, Ristocetin (1.25 mg/ml) can promote platelet aggregation. c Representative graph of Flow cytometry analysis of PAC-1. d HMGB1 up-regulated the expression of platelet surface Pac-1 (n = 5, *P < 0.01 vs. ALB)

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