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Fig. 3 | Diagnostic Pathology

Fig. 3

From: Pulmonary epithelioid inflammatory myofibroblastic sarcoma with multiple bone metastases: case report and review of literature

Fig. 3

Immunohistochemical and FISH assay of tumor. The polygonal and epithelioid tumor cells were observed to be positive for Desmin diffusely (a) and ALK in smooth cytoplasmic pattern (b). c The spindle cells in pulmonary tumor were also found to be positive for ALK. However, the epithelioid tumor cells were negative for CD30 (d) and SMA (e) staining. f FISH assay with break-apart probe for ALK gene shows one intact yellow signal, one separated red and green signal per nucleus in tumor cells indicating the presence of a rearrangement of ALK gene. (a-e, immunohistochemical staining with original magnification × 400; f, FISH assay with original magnification × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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