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Table 2 Relationship between histological entities and MET protein expression and gene copy number in 209 patients with NSCLC

From: Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?

Histology versus MET expression (formalin)
  All MET positive MET negative
(formalin) (formalin)
Histology (%) 209 (94.1) 45 (21.5) 164 (78.5)
ADC 110 (48.2) 34 (16.2) 71 (34)
SCC 94 (42.3) 10 (4.8) 77 (36.8)
LCC 9 (4) 1 (0.5) 8 (3.8)
other 9 (4) 0 8 (3.8)
Histology versus MET expression (HOPE)
  All MET positive MET negative
(HOPE) (HOPE)
Histology (%) 209 (94.1) 77 (36.8) 132 (63.2)
ADC 110 (48.2) 54 (25.8) 51 (24.4)
SCC 94 (42.3) 23 (11) 64 (30.6)
LCC 9 (4) 0 (0) 9 (4.3)
other 9 (4) 0 (0) 8 (3.8)
Histology versus MET phosphorylation at Y1234/1235
  All Y1234/1235+ Y1234/1235-
Histology (%) 209 (94.1) 30 (14.4) 179 (85.6)
ADC 110 (48.2) 20 (9.6) 87 (41.6)
SCC 94 (42.3) 9 (4.3) 77 (36.9)
LCC 9 (4) 1 (0.5) 7 (3.3)
other 9 (4) 0 8 (3.8)
Histology versus MET phosphorylation at Y1349
  All Y1349+ Y1349-
Histology (%) 209 (94.1) 38 (18.1) 171 (81.8)
ADC 110 (48.2) 17 (8.1) 91 (43.5)
SCC 94 (42.3) 18 (8.6) 67 (32.1)
LCC 9 (4) 3 (1.4) 5 (2.4)
other 9 (4) 0 8 (3.8)
Histology versus MET gene copy number
  All FISH positive FISH positive
(amplification) (polysomy)
Histology (%) 209 (94.1) 8 (3.8) 5 (2.4)
ADC 110 (48.2) 5 (2.4) 3 (1.4)
SCC 94 (42.3) 3 (1.4) 0 (0)
LCC 9 (4) 0 (0) 2 (1)
other 9 (4) 0 (0) 0 (0)