Table 2 Relationship between histological entities and MET protein expression and gene copy number in 209 patients with NSCLC
Histology versus MET expression (formalin) | |||
| Â | All | MET positive | MET negative |
(formalin) | (formalin) | ||
Histology (%) | 209 (94.1) | 45 (21.5) | 164 (78.5) |
ADC | 110 (48.2) | 34 (16.2) | 71 (34) |
SCC | 94 (42.3) | 10 (4.8) | 77 (36.8) |
LCC | 9 (4) | 1 (0.5) | 8 (3.8) |
other | 9 (4) | 0 | 8 (3.8) |
Histology versus MET expression (HOPE) | |||
| Â | All | MET positive | MET negative |
(HOPE) | (HOPE) | ||
Histology (%) | 209 (94.1) | 77 (36.8) | 132 (63.2) |
ADC | 110 (48.2) | 54 (25.8) | 51 (24.4) |
SCC | 94 (42.3) | 23 (11) | 64 (30.6) |
LCC | 9 (4) | 0 (0) | 9 (4.3) |
other | 9 (4) | 0 (0) | 8 (3.8) |
Histology versus MET phosphorylation at Y1234/1235 | |||
| Â | All | Y1234/1235+ | Y1234/1235- |
Histology (%) | 209 (94.1) | 30 (14.4) | 179 (85.6) |
ADC | 110 (48.2) | 20 (9.6) | 87 (41.6) |
SCC | 94 (42.3) | 9 (4.3) | 77 (36.9) |
LCC | 9 (4) | 1 (0.5) | 7 (3.3) |
other | 9 (4) | 0 | 8 (3.8) |
Histology versus MET phosphorylation at Y1349 | |||
| Â | All | Y1349+ | Y1349- |
Histology (%) | 209 (94.1) | 38 (18.1) | 171 (81.8) |
ADC | 110 (48.2) | 17 (8.1) | 91 (43.5) |
SCC | 94 (42.3) | 18 (8.6) | 67 (32.1) |
LCC | 9 (4) | 3 (1.4) | 5 (2.4) |
other | 9 (4) | 0 | 8 (3.8) |
Histology versus MET gene copy number | |||
| Â | All | FISH positive | FISH positive |
(amplification) | (polysomy) | ||
Histology (%) | 209 (94.1) | 8 (3.8) | 5 (2.4) |
ADC | 110 (48.2) | 5 (2.4) | 3 (1.4) |
SCC | 94 (42.3) | 3 (1.4) | 0 (0) |
LCC | 9 (4) | 0 (0) | 2 (1) |
other | 9 (4) | 0 (0) | 0 (0) |