Table 1 Different approaches to the treatment of acute myeloid leukemia between time periods
Time periods | Treatment |
|---|---|
Induction Remission: | |
Until 1985 | TAD protocol: |
- Thioguanine 100 mg/m2 orally every 12 hours for 7 days | |
- Cytarabine 100 mg/m2/d iv for 7 days | |
- Doxorubicin 30 mg/m2/d iv for 3 days | |
After 1985 | 7 + 3 protocol: |
- Cytarabine 200 mg/m2/d iv for 7 days | |
- Daunorubicin 45 mg/m2/d or doxorubicin 30 mg/m2 iv for 3 days | |
Residual leukemia | 5 + 2 protocol: |
- Cytarabine 200 mg/m2/d iv for 5 days | |
- Daunorubicin 45 mg/m2/d or doxorubicin 30 mg/m2/d iv for 2 days | |
Post-remission treatment: | |
Until 1985 | 12 maintenance cycles of TAD |
1986 to 1992 | 4 courses: |
- Cytarabine 400 mg/m2/d iv for 3 days | |
- Doxorubicin 30 mg/m2/d iv for 3 days | |
1993 to 1998 | 2-4 courses: |
- High-dose cytarabine 1 g/m2 iv every 12 hours for 4 days | |
- Doxorubicin 30 mg/m2/d iv for 3 days | |
After 1999 | 2-4 courses: |
- High-dose cytarabine 3 g/m2 iv every 12 hours on days 1, 3 and 5 |