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Table 1 Different approaches to the treatment of acute myeloid leukemia between time periods

From: Evaluation of bone marrow aspirates in patients with acute myeloid leukemia at day 14 of induction therapy

Time periods Treatment
  Induction Remission:
Until 1985 TAD protocol:
- Thioguanine 100 mg/m2 orally every 12 hours for 7 days
- Cytarabine 100 mg/m2/d iv for 7 days
- Doxorubicin 30 mg/m2/d iv for 3 days
After 1985 7 + 3 protocol:
- Cytarabine 200 mg/m2/d iv for 7 days
- Daunorubicin 45 mg/m2/d or doxorubicin 30 mg/m2 iv for 3 days
Residual leukemia 5 + 2 protocol:
- Cytarabine 200 mg/m2/d iv for 5 days
- Daunorubicin 45 mg/m2/d or doxorubicin 30 mg/m2/d iv for 2 days
  Post-remission treatment:
Until 1985 12 maintenance cycles of TAD
1986 to 1992 4 courses:
- Cytarabine 400 mg/m2/d iv for 3 days
- Doxorubicin 30 mg/m2/d iv for 3 days
1993 to 1998 2-4 courses:
- High-dose cytarabine 1 g/m2 iv every 12 hours for 4 days
- Doxorubicin 30 mg/m2/d iv for 3 days
After 1999 2-4 courses:
- High-dose cytarabine 3 g/m2 iv every 12 hours on days 1, 3 and 5
  1. iv intravenous infusion