Skip to main content

Table 5 Factors associated with poor outcome (overall survival) in patients with acute myeloid leukemia by univariate analysis

From: Evaluation of bone marrow aspirates in patients with acute myeloid leukemia at day 14 of induction therapy

Variable HR 95.0 % CI P value
Age > 60 years 1.685 1.203 2.362 0.002
Male gender 1.068 0.799 1.428 0.66
Year of treatment 1.317 1.096 1.582 0.003
Treatment delay > 7 days from diagnosis 1.551 1.031 2.333 0.03
Comorbidities     
Cardiac disease 1.534 1.082 2.174 0.02
Lung disease 1.924 0.937 3.95 0.07
Liver disease 0.880 0.326 2.372 0.80
Kidney disease 2.648 0.976 7.184 0.06
Diabetes 1.371 0.744 2.528 0.31
At least one comorbidity 1.596 1.153 2.211 0.005
MDS-related AML 1.338 0.904 1.979 0.15
Initial clinical manifestations     
Fever 1.265 0.928 1.725 0.14
Gingival hyperplasia 1.268 0.881 1.825 0.20
Lymphadenomegaly 0.867 0.644 1.166 0.34
Hepatomegaly 1.793 1.339 2.400 0.001
Splenomegaly 1.365 0.991 1.88 0.06
Pulmonary involvement 0.668 0.166 2.693 0.57
Cutaneous involvement 0.790 0.404 1.544 0.49
CNS involvement 0.475 0.066 3.401 0.46
Active bleeding 1.589 1.189 2.123 0.002
DIC 0.606 0.225 1.635 0.32
Infection at diagnosis     
Pharyngitis 1.139 0.691 1.876 0.61
Gastrointestinal 2.842 1.439 5.614 0.003
Fever of unknown origin 1.096 0.761 1.578 0.62
Blood 0.632 0.201 1.982 0.43
Skin and soft tissue 0.877 0.575 1.337 0.54
Pneumonia 1.490 0.995 2.23 0.05
Sinusitis 0.392 0.055 2.799 0.35
Oral cavity 0.775 0.462 1.298 0.33
Urinary tract 0.994 0.408 2.421 0.99
At least one infection 1.142 0.843 1.548 0.39
FAB classification     
M0 0.563 0.203 1.560 0.27
M1 0.747 0.367 1.520 0.42
M2 0.524 0.339 0.809 0.004
M4 0.796 0.539 1.177 0.25
M5 1.560 0.963 2.528 0.71
M6 0.888 0.321 2.461 0.82
M7 1.294 0.554 3.025 0.55
Laboratory abnormalities     
Leukocytes 1.000 1.000 1.00 0.13
Neutrophils 0.994 0.985 1.003 0.21
Hemoglobin 1.007 0.981 1.034 0.60
Platelets 1.001 0.999 1.002 0.22
Neutropenia 1.049 0.775 1.419 0.76
Leukocytosis (≥50 × 109/L) 1.220 0.890 1.673 0.22
LDH 1.000 1.000 1.001 0.07
% blasts D14 (observer 1) 1.018 1.009 1.027 0.001
% blasts D14 (observer 2) 1.014 1.007 1.022 0.001
Likert scale D14 (observer 1) 1.197 1.032 1.387 0.02
Likert scale D14 (observer 2) 1.339 1.147 1.563 0.001
  1. HR hazard ratio, 95 % CI 95 % confidence interval, CNS central nervous system, DIC disseminated intravascular coagulation FAB French–American–British, LDH lactate dehydrogenase