Table 2 Clinical and genetic characteristics of patients carrying KIF5B-RET fusion gene
From: KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas
No | Clinical characteristics | Genetic characteristics | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Sex/Age | Smoking | Histology | KIF5B-RET fusion gene | EGFR mutation | KRAS mutation | ALK rearrangement | OSa (mo) | DFSb (mo) | ||
Break apart probe (%) | Fusion probe (%) | |||||||||
1 | F/58 | Never-smoker | Acinar | 23.0 | 40.3 | Wild | Wild | negative | 8.7 | 7.33 |
2 | M/82 | current | Acinar | 27.1 | 22.2 | Wild | Wild | negative | 114.5 | 110.8 |
3 | M/63 | Ex-smoker | Acinar | 21.0 | 38.9 | Wild | Wild | negative | 53.4 | 15.23 |
4 | F/71 | Never-smoker | Acinar& lepidic | 15.3 | 49.2 | E19del | Wild | negative | 9.6 | 9.63 |
5 | M/56 | Ex-smoker | Papillary | 29.2 | 58.7 | E19del | Wild | negative | 11.2 | 10.8 |
6 | F/57 | Never-smoker | Acinar& lepidic | 17.8 | 46.9 | L858R or L861Q | Wild | negative | 2.6 | 2.63 |
7 | F/74 | Never-smoker | Acinar& lepidic | 37.8 | 41.7 | L858R or L861Q | Wild | negative | 5.9 | 5.9 |
K15 | F/74 | Never-smoker | Acinar | 14.8 | 72.4 | L858R | Wild | - | FU loss | FU loss |
8 | M/70 | Ex-smoker | Papillary | 29.4 | 29.1 | Wild | Codon12 | negative | 30.1 | 29.37 |