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Table 3 Univariate and multivariate analysis for the prognostic significance of clinicopathological characteristics and serum miR-150 levels in HCC

From: microRNA-150: a promising novel biomarker for hepatitis B virus-related hepatocellular carcinoma

Parameter

Univariate analysis

Multivariate analysisa

HR (95 % CI)b

P-value

HR (95 % CI)b

P-value

Genderc

0.638 (0.358–1.136)

0.127

  

Agec

0.892 (0.520–1.528)

0.677

  

AFPc

1.693 (0.903–3.173)

0.095

  

Tumor diameterc

1.567 (0.909–2.703)

0.106

  

Differentiationc

1.560 (0.908–2.679)

0.107

  

BCLC stagesc

3.284 (1.830–5.540)

<0.001d

2.631 (1.309–5.286)

0.006d

TNM stagesc

3.133 (1.803–5.444)

<0.001d

2.180 (1.129–4.210)

0.020d

miR-150

0.329 (0.189–0.571)

<0.001d

0.446 (0.233–0.854)

0.015d

  1. aBackward Wald test used for variables screened, P = 0.05 was chosen as a criteria for significance; bCI, 95 % confidence interval; cgender, male vs. female; age, ≥60 vs. <60 years; AFP, ≥20 vs. <20 ng/ml; tumor diameter, ≥5 vs. <5 cm; differentiation, poor vs. moderate and well; BCLC stage, B vs. A; TNM stage, III vs. I and II; d P < 0.05