Table 2 Distribution of SNPs of Numb gene for study population
Varients | Â | Total N (%) | Male N (%) | Female N (%) | P value |
|---|---|---|---|---|---|
rs2108552 (SNP1) | |||||
Genotype | C/C | 281 (17.0) | 174 (16.5) | 107 (18.0) | 0.732 |
| Â | G/G | 568 (34.4) | 367 (34.8) | 201 (33.7) | Â |
| Â | C/G | 799 (48.6) | 511 (48.7) | 288 (48.3) | Â |
Dominant model | CC | 281 (17.0) | 174 (16.5) | 107 (18.0) | 0.464 |
|  | CG + GG | 1367 (83.0) | 878 (83.5) | 489 (82.0) |  |
Recessive model | GG | 568 (34.4) | 367 (34.8) | 201 (33.7) | 0.634 |
|  | CG + CC | 1080 (65.6) | 685 (65.2) | 395 (66.3) |  |
Additive model | CG | 799 (48.6) | 511 (48.7) | 288 (48.3) | 0.922 |
|  | CC + GG | 849 (51.4) | 541 (51.3) | 308 (51.7) |  |
Allele | C | 1361 (41.3) | 859 (40.8) | 502 (42.1) | 0.471 |
| Â | G | 1935 (58.7) | 1245 (59.2) | 690 (57.9) | Â |
rs12435797 (SNP2) | |||||
Genotype | T/T | 532 (32.3) | 323 (30.7) | 209 (35.1) | 0.111 |
| Â | G/G | 348 (21.1) | 235 (22.3) | 113 (19.0) | Â |
| Â | G/T | 768 (46.6) | 495 (47.0) | 273 (45.9) | Â |
Dominant model | TT | 532 (32.3) | 323 (30.7) | 209 (35.1) | 0.063 |
|  | GT + GG | 1116 (67.7) | 730 (69.3) | 386 (64.9) |  |
Recessive model | GG | 348 (21.1) | 235 (22.3) | 113 (19.0) | 0.112 |
|  | GT + TT | 1300 (78.9) | 818 (77.7) | 482 (81.0) |  |
Additive model | GT | 768 (46.6) | 495 (47.0) | 273 (45.9) | 0.660 |
|  | TT + GG | 880 (53.4) | 558 (53.0) | 322 (54.1) |  |
Allele | T | 1832 (55.6) | 1141 (54.2) | 691 (58.1) | 0.031* |
| Â | G | 1464 (44.4) | 965 (45.8) | 499 (41.9) | Â |
rs1019075 (SNP3) | |||||
Genotype | C/C | 176 (10.7) | 115 (10.9) | 61 (10.2) | 0.846 |
| Â | T/T | 848 (51.5) | 536 (51.0) | 312 (52.3) | Â |
| Â | C/T | 624 (37.9) | 401 (38.1) | 223 (37.4) | Â |
Dominant model | CC | 176 (10.7) | 115 (10.9) | 61 (10.2) | 0.660 |
|  | CT + TT | 1472 (89.3) | 937 (89.1) | 535 (89.8) |  |
Recessive model | TT | 848 (51.5) | 536 (51.0) | 312 (52.3) | 0.585 |
|  | CT + CC | 800 (48.5) | 516 (49.0) | 284 (47.7) |  |
Additive model | CT | 624 (37.9) | 401 (38.1) | 223 (37.4) | 0.778 |
|  | CC + TT | 1024 (62.1) | 651 (61.9) | 373 (62.6) |  |
Allele | C | 976 (29.6) | 631 (30.0) | 345 (28.9) | 0.527 |
| Â | T | 2320 (70.4) | 1473 (70.0) | 847 (71.1) | Â |
rs17781919 (SNP4) | |||||
Genotype | C/C | 1621 (98.4) | 1034 (98.0) | 587 (99.0) | 0.133 |
| Â | C/T | 27 (1.6) | 21 (2.0) | 6 (1.0) | Â |
Allele | C | 3269 (99.2) | 2089 (99.0) | 1180 (99.5) | 0.135 |
| Â | T | 27 (0.8) | 21 (1.0) | 6 (0.5) | Â |