Table 3 Summary of reported cases of cervical adenoid cystic carcinoma coexisting with invasive squamous cell carcinoma
Author | Age | Symptom | Tumor type/size | Clinical stage | HPV result | Microscopic appearance | Treatment method | Status(duration of survival) |
|---|---|---|---|---|---|---|---|---|
Grayson, W et al. [16] | 68 | NA | NA | NA | HPV16 in both | ACC + SCC + CIS + sarcoma | NA | NA |
55 | NA | NA | NA | HPV16 in both | ACC + SCC + CIS + focal ABC + sarcoma | NA | NA | |
36 | NA | NA | NA | Neg | ACC + SCC + sarcoma | NA | NA | |
Yang, Y. J et al. [17] | 36 | NA | No gross nodular | NA | Neg | ACC + SCC + CIS + condyloma | Surgery | No |
Grayson, W et al. [18] | NA | NA | NA | NA | HPV16 in both | ACC + superficially invasive SCC | NA | NA |
Seth, A et al. [19] | 24 | Bleeding | Exophytic/3 cm | NA | NA | ACC + focal SCC | Surgery | NA |
Grayson, W et al. [4] | NA | NA | NA | NA | NA | 6 of 18 ACC showed ACC + invasive SCC, 1 case showed ACC + invasive SCC + ABC | NA | NA |
Mathoulin-Portier, M. P et al. [20] | 73 | Bleeding | Necrotic mass/5 cm | NA | NA | ACC+ a RARE focal SCC + sarcoma | Surgery | Metastasis 12 months later, Live with disease 36 months |
Manhoff, D. T et al. [21] | 80 | Bleeding | Protruded mass/NA | NA | NA | ACC + focally invasive SCC+ malignant stroma | Surgery + Radiation | NED, 6 months |
Albores-Saavedra et al. [22] | NA | NA | NA | NA | NA | 3 of 7 patients showed ACC + focal invasive SCC | NA | NA |
Ferry, J. A et al. [23] | NA | NA | NA | NA | NA | 1 of 14 patients showed ACC + SCC + CIS + ABC | NA | NA |
Musa, A. G et al. [24] | NA | NA | NA | NA | NA | 2 of 17 patients showed ACC + invasive SCC | NA | NA |
Berchuck, A et al. [25] | 72 | Bleeding | Exophytic/9.5 cm | FIGO IIIB | NA | ACC+ large cell SCC | Surgery + Radiation | NED, 6 months |
Mazur, M. T et al. [26] | 76 | Spotting | No visible tumor/NA | NA | NA | ACC + small foci of invasive SCC + CIS | Surgery + Radiation | NA |
Miles, P. A et al. [27] | NA | NA | NA | NA | NA | 3 of 12 showed ACC+ invasive SCC | NA | NA |
Hoskins, W. J et al. [28] | 54 | NA | NA | FIGO IB | NA | Adenosquamous carcinoma and the adeno component is ACC | Surgery + Radiation | NED, 12 months |
Bittencourt, A. L et al. [29] | 60 | Bleeding | Fragile mass/7 cm | FIGO IB | NA | ACC + invasive SCC | Surgery + Radiation | NED, 9 months |
72 | Bleeding | NA | FIGO IB | NA | ACC + invasive SCC | Radiation | NED, 27 months | |
Tchertkoff and Sedlis [30] | 63 | Bleeding | NA | NA | NA | ACC + invasive SCC | Surgery | Metastasis 3 years later live with disease |
Fowler, W. C et al. [31] | NA | NA | NA | NA | NA | 1 of 9 patient showed ACC+ invasive SCC | NA | NA |
Shingleton, H. M et al. [32] | 78 | Bleeding | Fungated mass/NA | FIGO III | NA | ACC+ focal SCC | Radiation | DOD, 3 months |
65 | Spotting | NA | FIGO IIB | NA | ACC+ focal SCC | Surgery + Radiation | NED | |
64 | NA | NA | NA | NA | ACC+ poorly differentiated SCC | Surgery + Radiation | DOD, 5 months | |
Ramzy, I et al. [33] | 68 | Bleeding | No visible tumor | NA | NA | ACC + invasive SCC | Surgery + Radiation | DOD, 27 months |