Table 1 Characteristics of studies included in the meta-analysis
Study | Year | Country | No. of patients | Age (year) | Technique | Cut-off value | No. of HER-2 Positive (%) | Follow-up period (month) | Outcome |
|---|---|---|---|---|---|---|---|---|---|
Baiocchi | 2009 | Brazil | 109 | NA | IHC | >10 % | Positive (%) | 57.4 (median) | OS |
Chen | 2010 | China | 44 | 55 (median) | IHC | 1+ | 14 (31.8) | 35 (median) | OS, CP |
Conradi | 2013 | Germany | 264 | 63 (mean) | IHC, S-ISH | 2+ | 70 (26.5) | 48.5 (median) | OS |
Drecoll | 2014 | Switzerland | 355 | 66 (median) | IHC, FISH | 2+ | 51 (14.4) | 87 (mean) | OS |
Ishida | 2000 | Japan | 149 | 61.6 (mean) | IHC | NA | 44 (29.5) | NA | OS, CP |
Ismail | 2007 | Egypt | 104 | 47.4 (mean) | IHC | 1+ | 10 (9.6) | 18 (median) | OS, CP |
Jesus | 2005 | Brazil | 108 | 63.1 (mean) | IHC | >10 % | 52 (48.1) | 28.1 (mean) | OS |
Kavanagh | 2009 | Ireland | 132 | 67.0 (mean) | IHC, FISH | 2+ | 18 (13.6) | NA | OS |
Lazaris | 1995 | Greece | 60 | 68.75 (mean) | IHC | >10 % | 21 (35) | 60 (median) | OS, CP |
Li | 2011 | China | 317 | 57.8 (mean) | IHC | 2+ | 49 (15.5) | 68.8 (median) | OS, CP |
Lim | 2013 | South Korea | 95 | 69 (median) | IHC, FISH | 2+ | 23 (24.2) | 22.7 (median) | OS, CP |
Lu | 2012 | China | 126 | NA | IHC | >25 % | 59 (46.8) | NA | OS, CP |
Mckay | 2002 | UK | 248 | NA | IHC | 2+ | 203 (81.9) | 43 (median) | OS, CP |
Osako | 1998 | Japan | 146 | 65.0 (mean) | IHC | NA | 100 (68.5) | 55.2 (median) | OS, CP |
Pappas | 2013 | Greece | 51 | 70.9 (mean) | IHC | 2+ | 2 (3.9) | 18 (median) | OS, CP |
Park | 2007 | South Korea | 137 | 62.4 (mean) | IHC, FISH | 2+ | 65 (47.4) | 48.5 (median) | OS, CP |
Rossi | 2002 | USA | 156 | 75 (median) | IHC | 1+ | 24 (15.4) | 46.8 (median) | OS |
Shin | 2014 | Korea | 266 | 63 (mean) | IHC | 2+ | 80 (30.1) | NA | OS, CP |