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Fig. 3 | Diagnostic Pathology

Fig. 3

From: p16INK4A expression is frequently increased in periorbital and ocular squamous lesions

Fig. 3

a, b Histology of an in-situ squamous cell carcinoma of the conjunctiva from a patient with HIV (4x and 20x, respectively). c, d Immunohistochemical staining for p16 in the same case (4x and 20x, respectively). Note the lack of p16 staining in adjacent normal conjunctiva with goblet cells. Arrows mark the transition between normal and dysplastic epithelium. e, f Immunohistochemical staining for Ki-67 (MIB-1). Note full-thickness reactivity in dysplastic epithelium

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