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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient

Fig. 2

Histology and polymerase chain reaction (PCR) analysis of the lesion at initial presentation. Hematoxylin and eosin staining (a, b). (a) Original magnification, ×100. (b) Original magnification, ×400. Immunohistochemistry for CD20 (c), CD138 (d), and Ki-67 (e) (original magnification, ×400). In situ hybridization analyses for Epstein-Barr virus-encoded RNA (EBER) (f) and immunoglobulin κ (g) and λ (h) light chain (original magnification, ×400). PCR analysis for immunoglobulin heavy chain rearrangements (i). The lesion was a solid tumor with an ulcertic surface (a). Immunoblastic cells with prominent nucleoli (b) were negative for CD20 (c) but positive for CD138 and EBER (d, f) with a high Ki-67 index (e). Cytoplasmic immunoglobulin light chain was absent (e, g). Monoclonal IgH chain gene rearrangement was demonstrated (i)

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