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Table 4 Monoclonal gene rearrangement results in negative, dual positive, and difficult to interpret surface light chains staining group

From: Inconclusive flow cytometric surface light chain results; can cytoplasmic light chains, Bcl-2 expression and PCR clonality analysis improve accuracy of cytological diagnoses in B-cell lymphomas?

   sIg LCs staining groups  
Gene rearrangement Final diagnosis Negative (N1/N) Dual positive (N1/N) Difficult to interpret (N1/N) Total (N1/N)
monoclonal B cells B-cell lymphoma 7/10 13/15 3/5 23/30
Reactive 5/53 2/5 1/10 8/68
total 12/63 15/20 4/15 30/98
monoclonal T cells B-cell lymphoma 1/10 2/15a 0/5 3/30
reactive 9/53 0/5 0/10 9/68
total 10/63 2/20 0/15 12/98
  1. N 1 lymphoma cases, N all cases in the group, sIg LCs surface immunoglobulin light chains, BCL B-cell lymphomas, RLP reactive lymphocytic proliferations
  2. aCase of composite MZL and T-cell lymphoma