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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Four cases of cell cannibalism in highly malignant feline and canine tumors

Fig. 1

Case 1. Solid mammary carcinoma. Cat. a – A small number of round tumor cells can be seen containing other tumor cells within a vacuole (arrows), giving the enclosing cell a signet ring-like appearance (HE). b – Cytology smear of the tumor in which a cell can be seen engulfing another (arrow) (Giemsa). c - IHC, anti-pancytokeratin antibody. Tumor cells stain positive, including internalized cells, one to the left and two to the right of the image. Mayer’s hematoxylin counterstain. d - IHC, anti-E-cadherin. Tumor cells show either homogenous cytoplasmic staining (lower arrow) or are almost completely negative (upper arrow) in contrast with the positive membrane staining of the surrounding tumor cells. Mayer’s hematoxylin counterstain

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