Nevi | Primary melanomas | Metastases | p-values | AUC [95 % C.I.] | ||
---|---|---|---|---|---|---|
Ki-67 index | Mean [95%C.I.] | 1.7 % [1.3–2.1] | 21.7 % [18.9–24.3] | 29.9 % [24.9–35] | p < 0.001 | - nevi vs primary melanomas : 0.959 [0.925–0.981] - benign vs malignant tumours (with metastases): 0.966 [0.94–0.983] |
p16 (% of stained cells) | Mean [95%C.I.] | 60.5 % [54.4–66.7] | 24.8 % [18.9–30.7] | 16.2 % [9.1–23.3] | p < 0.001 | - nevi vs primary melanomas : 0.778 [0.719–0.830] - benign vs malignant tumours (with metastases): 0.804 [0.756–0.847] |
HMB45 gradient | Yes: | 44.6 % | 10.3 % | N. A. | p < 0.001 | 0.74 [0.678–0.795] |
Doubtful: | 24.3 % | 14.7 % | ||||
No: | 31.1 % | 75 % | ||||
p16-Ki67 combined score | Score 0: | 48.6 % | 0 % | 0 % | - | 0.982 [0.955–0.995] |
Score 1: | 33.8 % | 0 % | 0 % | |||
Score 2: | 16.2 % | 10.9 % | 3.8 % | |||
Score 3: | 0 % | 10.9 % | 6.4 % | |||
Score 4: | 0 % | 26.9 % | 21.8 % | |||
Score 5: | 0 % | 13.5 % | 15.4 % | |||
Score 6: | 1.4 % | 14.7 % | 16.7 % | |||
Score 7: | 0 % | 23.1 % | 35.9 % | |||
p16-Ki67-HMB45 combined score | Score 0: | 20.2 % | 0 % | N.A. | - | 0.987 [0.963–0.997] |
Score 1: | 25.7 % | 0 % | ||||
Score 2: | 35.1 % | 0 % | ||||
Score 3: | 16.2 % | 1.3 % | ||||
Score 4: | 1.4 % | 13.5 % | ||||
Score 5: | 0 % | 13.5 % | ||||
Score 6: | 0 % | 26.9 % | ||||
Score 7: | 0 % | 16.7 % | ||||
Score 8: | 1.4 % | 12.8 % | ||||
Score 9: | 0 % | 15.4 % |