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Table 2 Summary of the results

From: A p16-Ki-67-HMB45 immunohistochemistry scoring system as an ancillary diagnostic tool in the diagnosis of melanoma

  

Nevi

Primary melanomas

Metastases

p-values

AUC [95 % C.I.]

Ki-67 index

Mean [95%C.I.]

1.7 % [1.3–2.1]

21.7 % [18.9–24.3]

29.9 % [24.9–35]

p < 0.001

- nevi vs primary melanomas : 0.959 [0.925–0.981]

- benign vs malignant tumours (with metastases): 0.966 [0.94–0.983]

p16 (% of stained cells)

Mean [95%C.I.]

60.5 % [54.4–66.7]

24.8 % [18.9–30.7]

16.2 % [9.1–23.3]

p < 0.001

- nevi vs primary melanomas : 0.778 [0.719–0.830]

- benign vs malignant tumours (with metastases): 0.804 [0.756–0.847]

HMB45 gradient

Yes:

44.6 %

10.3 %

N. A.

p < 0.001

0.74 [0.678–0.795]

Doubtful:

24.3 %

14.7 %

No:

31.1 %

75 %

p16-Ki67 combined score

Score 0:

48.6 %

0 %

0 %

-

0.982 [0.955–0.995]

Score 1:

33.8 %

0 %

0 %

Score 2:

16.2 %

10.9 %

3.8 %

Score 3:

0 %

10.9 %

6.4 %

Score 4:

0 %

26.9 %

21.8 %

Score 5:

0 %

13.5 %

15.4 %

Score 6:

1.4 %

14.7 %

16.7 %

Score 7:

0 %

23.1 %

35.9 %

p16-Ki67-HMB45 combined score

Score 0:

20.2 %

0 %

N.A.

-

0.987 [0.963–0.997]

Score 1:

25.7 %

0 %

Score 2:

35.1 %

0 %

Score 3:

16.2 %

1.3 %

Score 4:

1.4 %

13.5 %

Score 5:

0 %

13.5 %

Score 6:

0 %

26.9 %

Score 7:

0 %

16.7 %

Score 8:

1.4 %

12.8 %

Score 9:

0 %

15.4 %