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Table 2 Summary of the results

From: A p16-Ki-67-HMB45 immunohistochemistry scoring system as an ancillary diagnostic tool in the diagnosis of melanoma

   Nevi Primary melanomas Metastases p-values AUC [95 % C.I.]
Ki-67 index Mean [95%C.I.] 1.7 % [1.3–2.1] 21.7 % [18.9–24.3] 29.9 % [24.9–35] p < 0.001 - nevi vs primary melanomas : 0.959 [0.925–0.981]
- benign vs malignant tumours (with metastases): 0.966 [0.94–0.983]
p16 (% of stained cells) Mean [95%C.I.] 60.5 % [54.4–66.7] 24.8 % [18.9–30.7] 16.2 % [9.1–23.3] p < 0.001 - nevi vs primary melanomas : 0.778 [0.719–0.830]
- benign vs malignant tumours (with metastases): 0.804 [0.756–0.847]
HMB45 gradient Yes: 44.6 % 10.3 % N. A. p < 0.001 0.74 [0.678–0.795]
Doubtful: 24.3 % 14.7 %
No: 31.1 % 75 %
p16-Ki67 combined score Score 0: 48.6 % 0 % 0 % - 0.982 [0.955–0.995]
Score 1: 33.8 % 0 % 0 %
Score 2: 16.2 % 10.9 % 3.8 %
Score 3: 0 % 10.9 % 6.4 %
Score 4: 0 % 26.9 % 21.8 %
Score 5: 0 % 13.5 % 15.4 %
Score 6: 1.4 % 14.7 % 16.7 %
Score 7: 0 % 23.1 % 35.9 %
p16-Ki67-HMB45 combined score Score 0: 20.2 % 0 % N.A. - 0.987 [0.963–0.997]
Score 1: 25.7 % 0 %
Score 2: 35.1 % 0 %
Score 3: 16.2 % 1.3 %
Score 4: 1.4 % 13.5 %
Score 5: 0 % 13.5 %
Score 6: 0 % 26.9 %
Score 7: 0 % 16.7 %
Score 8: 1.4 % 12.8 %
Score 9: 0 % 15.4 %