Table 2 Differential diagnosis of Merkel cell carcinoma based on the tumor cells immunoprofile [2–34]
From: Unexpected maspin immunoreactivity in Merkel cell carcinoma
IHC marker | MCC | BCC with neuroendocrine differentiation | Melanoma | SCLC - skin metastasis |
|---|---|---|---|---|
AE1/AE3 Keratin | + | + | ± | + |
Keratin 20 | ± | - | - | - |
Keratin 7 | ± | - | - | + |
EMA | + | + | - | + |
CEA | - | - | - | - |
Chromogranin | ± | ± | - | ± |
Synaptophysin | + | ± | - | ± |
NSE | ± | ± | - | ± |
CD56 | ± | ± | - | + |
CD99 | + | - | - | - |
Bcl-2 | ± | - | - | - |
S-100 protein | + | - | + | - |
TTF-1 | ± | - | - | + |
Vimentin | - | - | + | - |
TDT | ± | - | - | ± |
DOG-1 | - | ± | - | - |
HMB45 | - | - | ± | - |
Melan A | - | - | + | - |
E-cadherin | - | + | - | - |
Maspin | ± | ± | ± | ± |
CD57 | ± | - | ± | ± |
PAX-5 | ± | - | - | - |
c-KIT | ± | - | ± | - |