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Fig. 1 | Diagnostic Pathology

Fig. 1

From: A promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix ----- CTCF transcriptional repressor regulates c-KIT proto-oncogene expression

Fig. 1

The analysis of the c-KIT proto-oncogene promoter region and the prediction of CTCF binding sites. The c-KIT proto-oncogene contains a long CpG island including promoter, first exon and first region ranging from −736 bp to 1224 bp. The CpG island region contains at least three putative transcriptional repressor CTCF binding sites predicted by the CTCFBSDB 2.0 database [1315]. The methylation-specific (MS) PCR primer sets were designed to be located in the region between the first Exon and first intron by using MethPrimer software [16, 17]. The blue box indicates the putative CTCF binding sites. *1 indicates the transcription start site of c-KIT proto-oncogene

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