Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11

Table 2 Genotypes of parental and villous tissue for additional STR loci

Locus	chr	Patient	Villi	Partner	Ploidy	Parental contributions
Trisomic chromosomes
D3S1300	3p	165 - 169	165 < 181	175 - 181	3n	M,P2,P2
D3S1314	3q	68 - 80	68 < 78	78 - 88	3n	M,P1,P1
D7S513	7p	152	136 - 140 - 152	136 - 140	3n	M,P1,P2
D7S669	7q	126	118 - 124 - 126	118 - 124	3n	M,P1,P2
D8S1786	8p	106	106 - 110 -116	110 - 116	3n	M,P1,P2
D8S1110	8q	270 - 274	258 - 270 - 274	258 - 270	3n	M,P1,P2
Disomic chromosome pairs with a maternal and paternal contribution
D1S1656	1	136 - 161	141 - 161	141 - 150	2n	M,P
D2S1391	2	118 - 122	106 - 122	106 - 126	2n	M,P
F13A1	6	283 - 287	279 - 283	279 - 287	2n	M,P
D9S171	9	165 - 173	163 - 173	157 - 163	2n	M,P
D10S189	10	180 - 186	178 - 180	178 - 184	2n	M,P
D13S158	13	122	116 - 122	116	NI	M,P
D14S51	14	93 - 95	95 - 99	93 - 99	2n	M,P
D15S125	15	123 - 129	129 - 131	131 - 133	2n	M,P
D17S799	17	184	184 - 190	190	NI	M,P
D19S221	19	198 - 206	194 - 206	192 - 194	2n	M,P
D20S481	20	231	219 - 231	219 - 235	2n	M,P
D21S167	21	160 - 177	160 - 179	175 - 179	2n	M,P
D22S264	22	186 - 196	196 - 204	194 - 204	2n	M,P
DXS451	X	188	174 - 188	174	NI	M,P
Chromosome 11
D11S922	11p	234 - 244	215	215 - 234	NI	P1
D11S2071	11p	170 - 189	194	166 - 194	NI	P2
D11S569	11p	137 - 146	144 - 148	144 - 148	2n	P1,P2
D11S916	11q	170 - 184	172	172	NI	P1
D11S925	11q	289	268	268	NI	P1
D11S934	11q	274 - 276	278 - 286	278 - 286	2n	P1,P2

Allele sizes are given in base pairs. chr, chromosome; M, maternal allele; P, paternal allele; P1, and P2, smaller and larger paternal allele respectively; NI, not informative

ISSN: 1746-1596