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Fig. 6 | Diagnostic Pathology

Fig. 6

From: Increasing diagnostic accuracy to grade dysplasia in Barrett’s esophagus using an immunohistochemical panel for CDX2, p120ctn, c-Myc and Jagged1

Fig. 6

Statistical analysis of IHC quantification using complete consensus samples. a Principal component analysis of quartile scoring method scores was generated from ND-BE (black circles), LGD (red circles), HGD (green circles) and EAC (blue circles) consensus samples. A demarcation line was added for easy visualization. b Beeswarm plot representing the distribution of ND-BE/LGD and HGD/EAC consensus samples when scored with the quartile scoring method. c Receiving operating characteristic curve depicting the accuracy of CDX2, p120ctn, c-Myc and Jagged1 expression scores as markers of diagnosis with a confidence interval of 95 % for the quartile scoring method. The area under curve for this ROC was 0.866. d PCA of IRS scores using IRS scoring, with circles representative of disease state as noted in (a). e Beeswarm plot when scored with the IRS scoring method (p ≤ 0.001). f ROC curve when scored with IRS scoring. The area under curve for this ROC was 0.956

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Diagnostic Pathology

ISSN: 1746-1596

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