Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis

Table 3 Correlation between histological features and molecular classification of HCA

	H-HCA (n = 5)	b-HCA/bIHCA (n = 2)	IHCA (n = 9)	UHCA (n = 1)	p value
Telangiectasia	0	50 % (1)	100 % (9)	0	0.0002
Inflammation	20 % (1)	50 % (1)	67 % (6)	100 % (1)	NS
Ductular Reaction	0	50 % (1)	44 % (4)	0	NS
Steatosis (mean %)	48 %	0	9 %	0	0.04
Atypical features	20 % (1)	100 % (2)	44 % (4)	0	NS
SAA positive (1+/2+)	60 % (3)	100 % (2)	89 % (8)	0	NS
GS positive (1+/2+)	40 % (2)	100 % (2)	56 % (5)	0	NS
LFABP loss	100 % (5)	0	0	0	0.0001

Abbreviations: SAA serum amyloid A, LFABP liver fatty acid-binding protein, GS glutamine synthetase, b-HCA beta-catenin activated hepatic adenoma, bIHCA HCA with mixed IHCA and b-HCA features, IHCA inflammatory HCA, H-HCA HNF1A inactivated HCA, UHCA unclassifiable HCA, NS not statistically significant (p value >0.05)

ISSN: 1746-1596