Automated quantification of proliferation with automated hot-spot selection in phosphohistone H3/MART1 dual-stained stage I/II melanoma

Table 5 Diagnostic performance of fully manual and fully automated hot-spot quantification

	Manual hot spot (cut-off, 1 cell per square)		Automated hot spot (cut-off, 2 cells per square)
		95 % CI		95 % CI
Sensitivity, %	95	84 - 99	67	52 - 81
Specificity, %	48	39 - 58	71	62 - 79
ROC area	0.83	0.76 - 0.90	0.74	0.65 - 0.83
Positive predictive value, %	42	32 - 52	48	35 - 61
Negative predictive value, %	96	88 - 100	85	76 - 91

Abbreviations: ROC receiver-operating characteristic, CI confidence interval

ISSN: 1746-1596