Fig 3From: Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcomaRepresentative images of poorly differentiated synovial sarcoma without cytokeratin expression. a: The tumor consisted of solid and fascicular proliferations of round to short-spindle tumor cells with round to oval nuclei. b: Tumor cells were negative for cytokeratin AE1/AE3 on IHC. c: Tumor cells were negative for EMA on IHC. d: FISH analysis revealed a pair of split and fused orange and green signals showing a SS18 split pattern (arrows)Back to article page