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Table 2 Comparison of the pathological diagnosis of the study sites and expert review by FISH analysis

From: Diagnostic use of fluorescence in situ hybridization in expert review in a phase 2 study of trabectedin monotherapy in patients with advanced, translocation-related sarcoma

Histological type

Study site

Expert review

FISH

Positive

Negative

ND

Myxoid liposarcoma

24

24

22

0

2

Synovial sarcoma

21

18

16

4a

1b

Mesenchymal chondrosarcoma

6

6

3

0

3

Extraskeletal Ewing sarcoma

5

5

4

0

1

Alveolar soft part sarcoma

5

5

5

0

0

Alveolar rhabdomyosarcoma

5

5

4

1

0

Clear cell sarcoma

5

5

5

0

0

Extraskeletal myxoid chondrosarcoma

2

2

1

1

0

Dermatofibrosarcoma protuberans

1

1

1

0

0

Angiomatoid fibrous histiocytoma

1

1

1

0

0

Desmoplastic small round cell tumor

1

1

1

0

0

Total

76

73

63

6

7

  1. aFour FISH-negative cases of synovial sarcoma included 2 MPNSTs, 1 sarcomatoid carcinoma, and 1 synovial sarcoma with SS18-SSX fusion detected by RT-PCR
  2. bOne FISH ND case with SS18-SSX fusion detected by RT-PCR
  3. ND, not detected, MPNST malignant peripheral nerve sheath tumor