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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Cutaneous clear cell/signet-ring cell squamous cell carcinoma arising in the right thigh of a patient with type 2 diabetes: combined morphologic, immunohistochemical, and etiologic analysis

Fig. 2

Histochemical and immunohistochemical profiles of clear cell/signet-ring cell SCC. The lesion was composed of diffused clear cells/signet cells (a, original magnification × 400). The septa of clear cells/signet-ring cells in serial sections were positive for PAS (b, original magnification × 400). They also expressed cytokeratin AE1/AE3, CK5/6, CK14, and CK19 (c–f, original magnification × 400). The lesion did not exhibit mutations of p53 (g, original magnification × 400). P63 positivity was detected in the nuclei of malignant cells (h, original magnification × 400). Clear cells/signet cells expressed strong-diffuse reactivity for FGFR2, a downstream effector of p63 (i, original magnification × 400). Less than 5 % of cancer cells expressed Ki-67 (j, original magnification × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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