Fig. 4

Immunostaining of EZH2 in benign lesions and high grade DCIS associated with triple-negative invasive breast carcinoma. Breast lobules, and UDH which showed benign proliferation of epithelial and myoepithelial cells without any atypia were shown (a and b). Breast lobules, and UDH expressed EZH2 in a low level, and only occasional EZH2 positive cells were observed (d and e). Representative high-grade DCIS associated with invasive triple-negative breast carcinoma showed solid growth pattern and central necrosis (c) (Magnification × 100). EZH2 was strongly overexpressed in high grade DCIS (f) (Magnification × 400)