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Fig. 4 | Diagnostic Pathology

Fig. 4

From: Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer

Fig. 4

Immunohistochemical analysis of CA IX and HIF-1α in HGPIN and Gleason pattern 3 to 5. Low cytoplasmic staining for CA IX and HIF-1α in HGPIN (a-c); low-to-moderate cytoplasmic staining, with few positive nuclei, for CA IX and HIF-1α in Gleason pattern 3 (d-f); strong cytoplasmic and nuclear expression of CA IX and HIF-1α in Gleason pattern 4 (g-i) and 5 (l-n) (a,d,g,l: hematoxylin and eosin (H&E); b,e,h,m: CA IX staining; c,f,i,n: HIF 1α staining. O.M. 200x)

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Diagnostic Pathology

ISSN: 1746-1596

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