Fig. 1
From: Surgical and molecular pathology of pancreatic neoplasms
a Macroscopic appearance of a pancreatic ductal adenocarcinoma showing a poorly demarcated firm white tumor in the pancreatic parenchyma (T Tumor, P pancreatic parenchyma, D duodenum). b Perineural invasion of a pancreatic ductal adenocarcinoma. c Positive TP53 immunohistochemistry in pancreatic ductal adenocarcinoma indicative of TP53 gene mutation. Arrow, malignant ductal structure; arrowhead, normal pancreatic duct. d Loss of SMAD4 immunohistochemistry in pancreatic ductal adenocarcinoma indicating mutation of the SMAD4 gene. Arrow, malignant ductal structure; arrowhead, normal pancreatic duct