Fig. 3
From: Surgical and molecular pathology of pancreatic neoplasms
Pancreatic cancer develops from the well-defined precursor lesions pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm. The PanIN progression model shown here shows that accumulation of genetic and epigenetic alterations drives neoplastic progression in these precursor lesions from low-grade dysplasia (PanIN 1 and PanIN 2) to high-grade dysplasia (PanIN 3) to eventually an invasive pancreatic adenocarcinoma