Fig. 5
From: Surgical and molecular pathology of pancreatic neoplasms
a Macroscopic appearance of a solid-pseudopapillary neoplasm showing a well demarcated tumor with solid, pseudopapillary and hemorrhagic-necrotic pseudocystic structures. b Microscopically, SPN is characterized by solid areas with relatively uniform cells with eosinophilic or clear vacuolated cytoplasm admixed with delicate capillaries and areas with extensive degenerative changes. The cells are poorly cohesive causing the pseudopapillary appearance. Note the eosinophilic globules (arrow). c Nuclear β-catenin expression in SPN (T tumor) and normal membranous labelling in adjacent normal pancreatic parenchyma