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Table 4 Mutations in pancreatic MEN1 syndrome associated microadenomas and PanNETs, sporadic PanNETs and PanNECs

From: Surgical and molecular pathology of pancreatic neoplasms

Neoplasm Mutations
MEN1 ATRX/DAXX mTOR pathway KRAS TP53 RB1
MEN1 syndrome microadenomas Up to 100 % 0 % u u u u
MEN-1 syndrome tumors Up to 100 % 6 % u u u u
G1/G2 Pancreatic neuroendocrine tumors 45 % 45 % 15 % 0 % 0 % 0 %
G3 Pancreatic neuroendocrine carcinomas u 0 % u 30 % 60 % 70 %
  1. u unknown