Table 4 Mutations in pancreatic MEN1 syndrome associated microadenomas and PanNETs, sporadic PanNETs and PanNECs
From: Surgical and molecular pathology of pancreatic neoplasms
| Neoplasm | Mutations | |||||
|---|---|---|---|---|---|---|
| MEN1 | ATRX/DAXX | mTOR pathway | KRAS | TP53 | RB1 | |
| MEN1 syndrome microadenomas | Up to 100 % | 0 % | u | u | u | u |
| MEN-1 syndrome tumors | Up to 100 % | 6 % | u | u | u | u |
| G1/G2 Pancreatic neuroendocrine tumors | 45 % | 45 % | 15 % | 0 % | 0 % | 0 % |
| G3 Pancreatic neuroendocrine carcinomas | u | 0 % | u | 30 % | 60 % | 70 % |