Table 4 Mutations in pancreatic MEN1 syndrome associated microadenomas and PanNETs, sporadic PanNETs and PanNECs
From: Surgical and molecular pathology of pancreatic neoplasms
Neoplasm | Mutations | |||||
|---|---|---|---|---|---|---|
MEN1 | ATRX/DAXX | mTOR pathway | KRAS | TP53 | RB1 | |
MEN1 syndrome microadenomas | Up to 100Â % | 0Â % | u | u | u | u |
MEN-1 syndrome tumors | Up to 100Â % | 6Â % | u | u | u | u |
G1/G2 Pancreatic neuroendocrine tumors | 45Â % | 45Â % | 15Â % | 0Â % | 0Â % | 0Â % |
G3 Pancreatic neuroendocrine carcinomas | u | 0Â % | u | 30Â % | 60Â % | 70Â % |