Nuclear size measurement for distinguishing urothelial carcinomas from reactive urothelium on tissue sections

Diagnostic Pathology

Table 1 Comparison of Mean Sizes for Nuclei From Reactive Urothelium, LGUC, HGUC and CIS

Cell type	# patients	# nuclei	L um	SD	95 % CI	W um	SD	95 % CI	Area um²	SD	95 % CI	Linear Ratio (L_nucleus)/, (W_nucleus)/L_lymphocyte ^a	Area ratio (A_nucleus/A_lymphocyte)^b
Reactive Urothelium	10	168	8.91	1.95	[8.62, 9.2]	5.75	1.29	[5.55, 5.95]	42.03	16.50	[39.5, 44.5]	1.85, 1.2	2.32
LG UCa	20	271	10.85	1.82	[10.63, 11.07]	6.92	1.20	[6.78, 7.06]	60.46	17.68	[58.36, 62.56]	2.26, 1.44	3.33
HG UCa	20	384	13.56	3.52	[13.21, 13.91]	8.82	2.54	[8.57, 9.07]	100.24	68.15	[93.42, 107.06]	2.82, 1.83	5.53
CIS	10	262	15.17	3.03	[14.8, 15.54]	9.35	2.22	[9.08, 9.62]	115.5	45.3	[110.01, 120.99]	3.15, 1.94	6.37

LG UC low-grade urothelial carcinoma, HG UC high-grade urothelial carcinoma, CIS carcinoma in situ, SD standard deviation, CI confidence interval, l length, w width, a area
^aMean l and w (um) of lymphocyte = 4.81
^bMean a (um²) of lymphocyte = 18.12

ISSN: 1746-1596