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Table 3 Univariate analysis of associations between clinicopathological variables and patient outcome (N = 124a)

From: Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer

  Relapse free survival Overall survival
Parameter p Hazard ratio (95 % CI) p Hazard ratio (95 % CI)
Gender 0.03    0.9   
 Female       
 Male   2.7 (1.1–6.8)   1.1 (0.5–2.4)
Age 0.06    0.3   
  > 65 years       
  < 65 years   2.8 (0.9–8.6)   1.5 (0.7–3.3)
Histology 0.01    0.04   
 Adenocarcinoma       
 Squamous cell carcinoma   0.7 (0.3–1.8)   0.5 (0.2–1.2)
 Large cell carcinoma   9.6 (2.7–34.0)   4.7 (1.1–20.1)
pTNM < 0.001    0.002   
 I       
 II   1.7 (0.6–4.5)   2.2 (0.8–5.7)
 III   8.8 (3.4–22.4)   7.1 (2.6–19.2)
pT 0.07    0.02   
 pT1      1.7 (0.6–5.6)
 pT2   2.4 (0.8–7.2)   5.6 (1.7–18.2)
 pT3   4.8 (1.4–16.3)    
 pT4       
pN 0.001    0.005   
 pN0       
 pN1   3.6 (1.4–9.1)   3.5 (1.4–8.9)
 pN2   8.2 (2.9–23.0)   5.1 (1.7–15.8)
Tumor size 0.18    0.73   
  ≤ 3.0 cm       
  ≥ 3.1 cm   1.7 (0.8–3.9)   1.2 (0.5–2.6)
DTCs detected by IMS 0.18    0.77   
 IMS negative       
 IMS positive   1.7 (0.8–3.8)   1.1 (0.5–2.5)
  1. aFour patients were excluded from survival analyses due to stage IV disease