Table 1 Frequency of BRAF V600E mutations in 969 CNS tumors
From: Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
| Â | n BRAF V600E/total | % | Mean age |
|---|---|---|---|
Neuroepithelial tumors: | 6/667 | 0.90 | 54 |
  Astrocytoma (WHO grade II) | 2/42 | 4.76 | 44 |
  Oligoastrocytoma (WHO grade II) | 0/12 | 0.00 | 41 |
  Oligodendroglioma (WHO grade II) | 0/19 | 0.00 | 41 |
  Anaplastic astrocytoma (WHO grade III) | 0/36 | 0.00 | 44 |
  Anaplastic oligoastrocytoma (WHO grade III) | 0/15 | 0.00 | 39 |
  Anaplastic oligodendroglioma (WHO grade III) | 0/40 | 0.00 | 51 |
  Glioblastoma (WHO grade IV) | 3/312 | 0.96 | 60 |
  Gliosarcoma (WHO grade IV) | 1/75 | 1.33 | 62 |
  Subependymoma (WHO grade I) | 0/5 | 0.00 | 53 |
  Myxopapillary ependymoma (WHO grade I) | 0/16 | 0.00 | 38 |
  Ependymoma (WHO grade II) | 0/46 | 0.00 | 50 |
  Anaplastic ependymoma (WHO grade III) | 0/13 | 0.00 | 39 |
  Choroid plexus papilloma (WHO grade I) | 0/28 | 0.00 | 47 |
  Choroid plexus papilloma (WHO grade II) | 0/6 | 0.00 | 41 |
  Choroid plexus carcinoma (WHO grade III) | 0/2 | 0.00 | 43 |
Cranial nerve tumors: | Â | Â | Â |
  Vestibular schwannoma (WHO grade I) | 0/50 | 0.00 | 44 |
Meningeal tumors: | 1/117 | 0.85 | 45 |
  Meningioma (WHO grade I) | 0/55 | 0.00 | 41 |
 Meningothelial | 0/28 | 0.00 | 40 |
 Transitional | 0/17 | 0.00 | 41 |
 Fibrous | 0/3 | 0.00 | 41 |
 Psammomatous | 0/3 | 0.00 | 48 |
 Microcystic | 0/2 | 0.00 | 45 |
 Not otherwise specified | 0/2 | 0.00 | 50 |
  Meningioma (WHO grade II) | 0/35 | 0.00 | 39 |
 Atypical | 0/26 | 0.00 | 35 |
 Chordoid | 0/2 | 0.00 | 43 |
 CNS infiltration | 0/2 | 0.00 | 45 |
 Not otherwise specified | 0/5 | 0.00 | 59 |
  Meningioma (WHO grade III) | 1/27 | 3.70 | 60 |
 Anaplastic | 0/24 | 0.00 | 62 |
 Rhabdoid | 1/3 | 33.33 | 36 |
Metastases: | 29/135 | 21.48 | 57 |
  Melanoma | 24/58 | 41.38 | 56 |
  NSCLC | 0/29 | 0.00 | 59 |
 Adeno Ca | 0/22 | 0.00 | 59 |
 Squamous cell Ca | 0/5 | 0.00 | 60 |
 Not otherwise specified | 0/2 | 0.00 | 58 |
  Breast Ca | 0/22 | 0.00 | 54 |
  Colorectal Ca | 2/4 | 50.00 | 51 |
  Sarcoma | 0/7 | 0.00 | 57 |
  Prostate Ca | 0/6 | 0.00 | 66 |
  Renal clear cell Ca | 0/3 | 0.00 | 71 |
  Esophageal adeno Ca | 1/2 | 50.00 | 46 |
  Hepatcellular Ca | 1/1 | 100.00 | 73 |
  Papillary thyroid Ca | 1/1 | 100.00 | 74 |
  Parotid acinic cell Ca | 0/1 | 0.00 | 41 |
  Ovarian Ca | 0/1 | 0.00 | 45 |