Skip to main content

Table 1 Summary of clinicopathological data and results of molecular investigation of non melanoma skin cancer

From: Frequent detection of human polyomavirus 6 in keratoacanthomas

References

Tumor type

HPyV6 DNA

Detection Methode

HPyV6 IHC 6V32

HPyV6-FISH

Clinical Data

Schowalter et al. [14]

NS (n = 35)

14,3 %

DNA-PCR

NA

NA

IC

Ser (n = 65)

69 %

VP1 ELISA

NA

Duncavage et al. [22]

MCC (n = 28)

3,5 %

rt-PCR

NA

NA

NA

Schrama et al. [24]

SCC (n = 21)

38 %

qPCR

NA

NA

NA

BCC (n = 18)

5,5 %

MCC (n = 20)

10 %

Scola et al. [25]

SCC (n = 52)

4 %

rt-PCR

NA

NA

IC

BCC (n = 41)

7 %

KA (n = 42)

5 %

Imajoh et al. [23]

NS (n = 34)

8,8 %

rt-PCR

NA

NA

NA

SCC (n = 63)

3,2 %

BCC (n = 50)

2 %

Nicol et al. [19]

Ser

37,5 % pos. (age 1–4)

VP1 ELISA

NA

NA

IC

61,8 % pos. (age 15–19)

67,1 % pos (age 30–38)

98,2 % pos. (age 80+)

Schrama et al. [28]

KA (n = 4)

25 %

rt-PCR

KA 1/4 (25 %)

NA

IS

  1. IS immunosuppressed, IC immunocompetent, PCR polymerase chain reaction, IHC immunohistochemistry, FISH fluorescence in situ hybridisation, rt-PCR real time PCR, qPCR quantitative PCR, ELISA enzyme-linked immunosorbent assay, HPyV6 human polyomavirus 6, NS normal skin, Ser serum, SCC squamous cell carcinoma, BCC basal cell carcinoma, KA keratoacanthoma, MCC Merkel cell carcinoma, NA not applicable