Expression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma

Diagnostic Pathology

Table 2 Correlation between EGFRvIII expression, AREG expression, AREG/EGFR co-expression and clinicopathologic factors in PDAC

Parameter	EGFRvIII		P	AREG		P	AREG/EGFR		P
Parameter	Negative	Positive	P	Negative	Positive	P	Negative^a	Positive^b
Overall	80	12		43	49		70	22
Age(years)			0.056			0.241			0.65
< 60	30	8		15	23		28	10
≥ 60	50	4		28	26		42	12
Gender			0.124			0.566			0.057
Male	39	3		22	28		34	16
Female	41	9		21	21		35	6
Tumor sites			0.625			0.256			0.09
Head	46	6		27	25		43	9
Body/tail	34	6		16	24		27	13
Tumor size			0.475			0.117			0.158
T1-2	21	2		14	9		20	3
T3-4	59	10		29	40		50	19
TNM stage			0.187			0.106			0.925
I-II	71	9		40	40		61	19
III-IV	9	3		3	9		12	3
Tumor differentiation			0.885			0.803			0.032
Well/morderate	55	8		30	33		52	11
Poor	25	4		13	16		18	11
Resection margins			0.067			0.457			0.851
Negative	62	12		36	38		56	18
Positive	18	0		7	11		14	4
Lymph node metastasis			0.828			0.725			0.923
No	36	5		20	21		31	10
Yes	44	7		23	28		39	12

ISSN: 1746-1596