Fig. 5

Patient 3 (a, b). a: Tumors of the sigmoid colon are characterized by a diffuse infiltrate of atypical medium-sized lymphocytes and increased atypical IELs. b: Infiltrating atypical lymphocytes are diffusely positive for CD56. Patient 4. c: A prominent increase in the number of small atypical IELs is seen in the cecal mucosa. d: Many small IELs are present in the descending colon. e: Reactive infiltrating IELs of the colon are positive for CD3 (a, c, d: H&E stain, b, e: immunohistochemistry, hematoxylin stain)