Fig. 1
From: Impact of tissue sampling on accuracy of Ki67 immunohistochemistry evaluation in breast cancer
Hexagonal tiling of digital image analysis data for tissue subsampling simulations. Left: Tumor marked by region of interest. Overlay showing high resolution tissue. Middle: Tumor with results of DIA and the hexagonal grid for TMA simulation. Overlay showing high resolution DIA results. Right: Hexagonal grid filtered according to nuclei count. Ki67 LI indicated by fill color. Light gray is low Ki67 LI with darker reds showing larger Ki67 LI. Green hexagons illustrate one possible subsampled set of four hexagons