Diagnostic Pathology

Table 1 Linear regression analysis results for hexagon size = 825 pixels (≈0.75 mm TMA core)

From: Impact of tissue sampling on accuracy of Ki67 immunohistochemistry evaluation in breast cancer

R² values
HexN	All tumor cases			Homogeneous cases			Heterogeneous cases
HexN	Sum	Mean	Median	Sum	Mean	Median	Sum	Mean	Median
1	0.827	0.827	0.827	0.906	0.906	0.906	0.6	0.6	0.6
2	0.893	0.888	0.888	0.929	0.926	0.926	0.749	0.733	0.733
3	0.93	0.92	0.9	0.964	0.955	0.947	0.81	0.79	0.731
4	0.955	0.952	0.945	0.969	0.969	0.965	0.897	0.879	0.866
5	0.964	0.958	0.938	0.972	0.969	0.963	0.926	0.912	0.842
6	0.964	0.957	0.951	0.975	0.972	0.969	0.916	0.895	0.886
7	0.964	0.959	0.952	0.976	0.969	0.969	0.918	0.913	0.883
8	0.969	0.958	0.95	0.981	0.977	0.977	0.916	0.882	0.845
9	0.976	0.971	0.966	0.984	0.98	0.981	0.944	0.934	0.908
10	0.978	0.971	0.962	0.987	0.983	0.98	0.947	0.923	0.893
11	0.974	0.968	0.961	0.983	0.978	0.977	0.936	0.92	0.894
12	0.977	0.971	0.968	0.982	0.976	0.977	0.954	0.941	0.926
13	0.982	0.978	0.969	0.986	0.984	0.984	0.965	0.95	0.914
14	0.98	0.975	0.969	0.986	0.984	0.984	0.952	0.938	0.907
15	0.982	0.977	0.973	0.984	0.983	0.983	0.965	0.95	0.933

In each data set Ki-67 LI was calculated by counting mean, median and sum of positive and negative cells. All linear regression analysis results were statistically significant, p < 0.0001

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ISSN: 1746-1596

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