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Table 1 Specificity/sensitivity/positive predictive value and negative predictive value for each transcript as detected by digital RNA quantification

From: Multiplexed automated digital quantification of fusion transcripts: comparative study with fluorescent in-situ hybridization (FISH) technique in acute leukemia patients

  No (n) Result (Pos./ Neg.) Sensitivity (%) Specificity (%) PPVa (%) NPVb (%)
Acute Myeloid Leukemia (AML)
 AML1-ETO 8 8/0 100 100 100 100
 PML-RARA 8 8/0 100 100 100 100
 CBFB-MYH11 7 4/3 57 100 100 97
Acute Lymphoblastic Leukemia (ALL)
 TCF3-PBX1 4 3/1 75 100 100 99
 MLL-AF4 7 6/1 85 100 100 99
 BCR-ABL 7 7/0 100 100 100 100
 ETV6-RUNX1 8 1/7 12 92 50 92
 AML - Normal Karyotype 19 0/19 N/A 100 N/A 100
 AML - Complex Karyotype 21 1/20 N/A 99 N/A 100
 Normal Bone Marrow 5 0/5 N/A 100 N/A 100
  1. a PPV positive predictive value; b NPV negative predictive value
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Diagnostic Pathology

ISSN: 1746-1596

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