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Table 6 Inter-laboratory performance results

From: Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma

Study outline Design Results, %
(95 % CI)
Inter-laboratory reproducibility (NSCLC)
(n = 3 labs, 2 pathologists per lab)
Each case tested 5 separate times
14 cases
7 PD-L1 high
7 PD-L1 low/negative
PPA 93.3 (89.0–95.9)
NPA 79.5 (73.6–84.4)
OPA 86.4 (82.7–89.3)
Inter-laboratory reproducibility (HNSCC)
(n = 3 labs, 2 pathologists per lab)
Each case tested 5 separate times
14 cases
7 PD-L1 high
7 PD-L1 low/negative
PPA 89.4 (84.4–92.9)
NPA 99.5 (97.3–99.9)
OPA 94.5 (91.8–96.3)
  1. HNSCC head and neck squamous cell carcinoma, NPA negative percentage agreement, NSCLC non-small cell lung cancer, OPA overall percentage agreement, PPA positive percentage agreement