Fig. 1
From: Primary alveolar rhabdomyosarcoma of the bone: two cases and review of the literature
Radiological image and hematoxylin-eosin stained specimen of the tumor. a Axial T2 SPAIR image of pelvis shows diffuse patchy infiltration (arrowheads) of the bone marrow. Some small necrotic areas are also visible. b The HE stained biopsy sample shows highly cellular infiltrate among the bony trabeculae repelling the normal hematopoietic cells (insert image). With higher magnification, the monomorphic tumor cells have a characteristic eosinophilic cytoplasm, however tumor cells also show intracytoplasmic vacuolization (arrowheads). The nuclei of tumor cells are eccentric in position, but rather identical in size and own a finely granulated, basophilic nuclear structure (arrows). Note that the organization of tumor cells represent a somewhat nest-like pattern, but lack fine fibrovascular stroma, that is characteristic of the solid variant of alveolar RMS. Bars indicate 50 μm, insert 100 μm