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Table 4 Group IV, cases diagnosed with mixed surface epithelial carcinomas

From: Systematic assessment of HER2/neu in gynecologic neoplasms, an institutional experience

Case no. HER2/neu Primary site Histopathology diagnosis
IHC FISH Result Type FIGO Nuc
1 2+ 7.41 POS Endometrium CCCA + SCA 3 3
2 1+ 1.02 NEG Ovary CCCA + SCA 3 3
3 0 1.37 NEG Pelvic mass CCCA + SCA 3 3
4 0 NP NEG Ovary CCCA + SCA 3 3
5 0 NP NEG Ovary CCCA + SCA 3 3
6 0 NP NEG Ovary CCCA + SCA 3 3
7a 0–3+ 1.38 NEG Endometrium CCCA + SCA 3 3
8 1+ 0.93 NEG Endometrium CCCA + ENAdCA 3 3
9 1+ NP NEG Endometrium CCCA + ENAdCA 3 3
10 1+ NP NEG Endometrium CCCA + ENAdCA 3 3
11 0 NP NEG Ovary CCCA + ENAdCA 3 3
12 1+ NP NEG Ovary CCCA + ENAdCA 3 3
13 0 NP NEG Ovary CCCA + ENAdCA 3 3
14 0 NP NEG Endometrium SCA + ENAdCA 3 3
15 1+ NP NEG Ovary SCA + ENAdCA 3 3
16 0 NP NEG Peritoneum SCA + ENAdCA 3 3
17 0 NP NEG Endometrium SCA + ENAdCA 3 3
18 0 NP NEG Ovary SCA + ENAdCA 3 3
19 1+ 1.7 NEG Endometrium SCA + ENAdCA 3 3
20a 0–3+ 1.14 NEG Endometrium SCA + ENAdCA 3 3
21 0 NP NEG Ovary SCA + ENAdCA 3 3
22 1+ 1.2 NEG Endometrium SCA + ENAdCA 3 3
23 0 1.04 NEG Ovary SCA + ENAdCA 3 3
24 1+ 1 NEG Ovary SCA + ENAdCA 3 3
25 1+ 1 NEG Ovary SCA + ENAdCA + Mu 3 3
26 0 1 NEG Endometrium ENAdCA + Mu 1 1
  1. Bold data signify the positive results
  2. IHC immunohistochemistry score, FISH fluorescence in-situ hybridization HER2/CEP17 ratio, FIGO FIGO grade, Nuc nuclear grade, NP not performed, POS positive, NEG negative, CCCA clear cell carcinoma, SCA serous carcinoma, ENAdCA endometrioid adenocarcinoma, Mu mucinous adenocarcinoma
  3. a Denotes intratumoral heterogeneity of HER2 reaction